Join our study and receive new potential treatment, free of charge!
Plaque Psoriasis - Study for adults with mild-to-moderate chronic plaque psoriasis
Psoriasis is a chronic inflammatory disease of skin and joints. It affects 1.5 to 3% of the general population in Europe and more than 125 million people worldwide. ZL-1102 (an IL-17 inhibitor) is being developed for the topical treatment of chronic plaque psoriasis of mild to moderate severity.
This study involves comparison of ZL-1102 Gel vs. placebo in a 1:1 ratio.
Inclusion Criteria
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Age between 18-75 years
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Stable chronic plaque psoriasis with:
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< 10% affected Body Surface area
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Suitable psoriatic Plaque:
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Lesion size: > 9cm2 to 100 cm2
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Lesion stable for ≥ 3 months
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Willing to complete a daily patient diary.
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Willing to avoid excess exposure to natural or artificial UV light during the treatment period.
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Exclusion Criteria
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Forms of psoriasis other than chronic plaque-type (e.g., pustular, erythrodermic and guttate psoriasis, palmar, plantar, scalp or nail disease)
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Drug-induced psoriasis
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Ongoing topical/systemic treatments
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Activate system infections/local infection of suitable plaque within 2 weeks of randomisation
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HIV/HBV/HCV positive
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Inability or unwillingness to undergo repeated venepuncture for skin biopsies.
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History or evidence of drug or alcohol abuse within 1 year prior to screening
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Have had a live vaccine 6 weeks prior to baseline
6 visits (Screening, Baseline, 3 Treatment and 1 Follow-up visit)
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Screening visits will take approximately 1 hour, (trial explanation, obtaining consent, gathering patient history, physical examination, total & local PASI score ECG and biological samples)
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Baseline & subsequent treatment visits will take approximately 45 minutes (AEs and con meds, physical exam, local PASI score & plaque size, photography of target sites, gathering biological samples).
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The last treatment visit will take approximately 4 hours – same procedures as above + 4-hour post treatment PK sampling.
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The follow-up visit will take approximately 30 minutes (AEs and con meds, physical exam, gathering biological samples, local PASI score & plaque size).
Total = ~8 hours distributed over 6 weeks